Analysis Method of Motion Information Driven by Medical Big Data

Identification of BKCa channel openers by molecular field alignment and patent data-driven analysis

In this work, we present the first comprehensive molecular field analysis of patent structures on how the chemical structure of drugs impacts the biological binding. This task was formulated as searching for drug structures to reveal shared effects of substitutions across a common scaffold and the chemical features that may be responsible. We used the SureChEMBL patent database, which prov...

Integrating Medical and Research Information: a Big Data Approach

Most of the information collected in different fields by Instituto de Investigación Biomédica de A Coruña (INIBIC) is classified as unstructured due to its high volume and heterogeneity. This situation, linked to the recent requirement of integrating it to the medical information, makes it necessary to implant specific architectures to collect and organize it before it can be analysed. The purp...

Visualizing abstract information using motion properties of data-driven infoticles

This paper presents a novel exploratory information visualization technique that allows users to analyze time-varying characteristics of large datasets within immersive virtual reality environments. This metaphor represents data objects as particles, coined infoticles, which are placed inside a three-dimensional scene. Forces correspond to specific data value conditions and influence matching i...

Reverse Translational Pharmacology Research Is Driven by Big Data

Pharmacology research usually translates in vitro pharmacology experiments or animal studies to human proof of principle or phase I clinical studies. This is often referred as the T1 translational research. The clinical pharmacokinetic (PK) or pharmacodynamic (PD) studies usually translate and sometimes even guide the phases II and III clinical studies. This is called T2 translational research....

Existence and Measurability of the Solution of the Stochastic Differential Equations Driven by Fractional Brownian Motion